KRYPTOR compact PLUS

KRYPTOR compact PLUS – measuring biomarkers in diverse clinical areas with

Reliability:

A range of assays is designed to run on our KRYPTOR system that is continually improved. Our improvements also reflect advances in healthcare and cover many clinical areas of importance. We work closely with the laboratories and clinical wards to understand needs and to transform them into the further development of our measuring system and biomarkers, always for the benefit of the doctor and the patient. We provide reliable measuring results for the following clinical areas:

• Diagnosis of sepsis in emergency departments and intensive care units
• Stratification and prioritization of patients in emergency rooms
• Confident follow-up testing of cancer diseases
• Reliable results and excellent precision for endocrine disorders
• Prenatal screening in fertility clinics, prenatal departments and OSCAR centers

Precision is vital for the clinical decision making process that is supported by the measuring result of a biomarker. This requires both a stable and well-defined biomarker assay and a platform that safeguards a reliable and precise measurement of the biomarker. Our platform B·R·A·H·M·S KRYPTOR compact PLUS is a fully automatic, closed laboratory analysis system that can perform numerous various analyses in random-access operations using a unique measuring principle called TRACE (Time Resolved Amplified Cryptate Emission). TRACE is based on a research for which the French chemist Jean-Marie Lehn received a Nobel Prize in Chemistry in 1987.

                                                       

Thermo Scientific B·R·A·H·M·S Biomarkers are proud to employ TRACE technology in their KRYPTOR systems worldwide, based on an exclusive license. Precision technology paves the way for the development of innovative in-vitro diagnostic reagents for diverse clinical areas.

What is TRACE technology?

  

Award-winning chemistry, results you can trust

TRACE technology is the Nobel Prize-winning chemistry underlying the precision and usability of the KRYPTOR compact PLUS. TRACE simplifies assay processing and ensures that only signals of interest are detected. So, how does it work?

Overcoming challenges in analyte detection

Using fluorophores to detect and quantify molecules of interest in biological samples can be confounded by unspecific signals or characteristics of the sample matrix itself. The problem is commonly solved by isolating the analyte bound to a fluorophore through a series of washing or separation steps that elimin
ate any background noise. This complicates the processing of tests, which makes room for errors, costs time, and generates wastes.

Isolating signals over time

Time-resolved amplified cryptate emission isolates the signal of interest by offsetting it from unspecific signals. Highly stable in biological samples, europium cryptate transfers energy to a fluorophore when both are bound to an analyte. This energy transfer dramatically lengthens the emission signal of the fluorophore. The KRYPTOR compact PLUS then delays detection by 50 µseconds, when unspecific signals are already extinguished and only signals relevant to analyte quantification 
are recorded.

Robust to sample variability

KRYPTOR compact PLUS detects two signals of each sample, which result from the binding of an immune complex with the analyte. The signals are generated by a fluorophore and an europium cryptate bound antibody. Fluorophore and cryptate signals are impacted by sample characteristics that hinder l
ight transmission, however the ratio of the two signals remains an accurate measure of the amount of analyte in a sample
regardless of the turbidity, color or other sample characteristic.

Tracking for intelligent sample management

The instrument has then the information needed to automatically dilute the sample and reinitiate analysis.

                                                          

 

Why use KRYPTOR?

Innovation working for you

With a small footprint and intelligent engineering, KRYPTOR compact PLUS is an established analyzer 
of our KRYPTOR instrument line that brings exceptional value to clinical laboratories. 

Obtain results that you can trust

• Nobel Prize-winning TRACE technology eliminates the need for wash or separation steps
• High-quality engineering ensures assay precision
• Automation and careful assay design guarantee lot-to-lot stability

Load your samples at any time

• A fully automated bench-top analyzer with easy and continuous sample loading

Use your time and reagents efficiently

• Minimal reagent use and small quantities of liquid waste
• Long time interval between easy, one- or two-point recalibrations
• Up to 12 cooled kits can be loaded for several hundred determinations

Our support team offers expert know-how and solutions

• Quickly access customer support via remote service
• Count on responsive and knowledgeable instrument support

Easily manage samples and workflows

• Low hands-on time and intuitive interface streamlines sample analysis
• STAT function to quickly analyze emergency samples
• Detection of out-of-range samples, which are automatically diluted in <5 minutes to deliver results fast
• Timely warning flags regarding issues with samples, such as presence of particles or bubbles
• Color-coded, real-time display of testing status

Biomarker Test Menu

For decades B·R·A·H·M·S has been a leader in the development of biomarkers with true clinical impact.
The portfolio of assays designed to run on KRYPTOR platforms continually improves to reflect advances in healthcare and covers a range of important indication areas.